Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.
Identifieur interne : 000978 ( Main/Exploration ); précédent : 000977; suivant : 000979Total saponins of panaxnotoginseng promotes lymphangiogenesis by activation VEGF-C expression of lymphatic endothelial cells.
Auteurs : Jinlong Li [République populaire de Chine] ; Yan Chen [République populaire de Chine] ; Li Zhang [République populaire de Chine] ; Lianping Xing [États-Unis] ; Hao Xu [République populaire de Chine] ; Yongjun Wang [République populaire de Chine] ; Qi Shi [République populaire de Chine] ; Qianqian Liang [République populaire de Chine]Source :
- Journal of ethnopharmacology [ 1872-7573 ] ; 2016.
Descripteurs français
- KwdFr :
- Animal génétiquement modifié, Animaux, Cellules endothéliales (enzymologie), Cellules endothéliales (métabolisme), Danio zébré (embryologie), Facteur de croissance endothéliale vasculaire de type C (métabolisme), Lignée cellulaire, Lymphangiogenèse (), Panax notoginseng (), Phosphatidylinositol 3-kinases (métabolisme), Saponines (pharmacologie), Souris, Système de signalisation des MAP kinases, Transduction du signal, p38 Mitogen-Activated Protein Kinases (métabolisme).
- MESH :
- embryologie : Danio zébré.
- enzymologie : Cellules endothéliales.
- métabolisme : Cellules endothéliales, Facteur de croissance endothéliale vasculaire de type C, Phosphatidylinositol 3-kinases, p38 Mitogen-Activated Protein Kinases.
- pharmacologie : Saponines.
- Animal génétiquement modifié, Animaux, Lignée cellulaire, Lymphangiogenèse, Panax notoginseng, Souris, Système de signalisation des MAP kinases, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Animals, Genetically Modified, Cell Line, Endothelial Cells (enzymology), Endothelial Cells (metabolism), Lymphangiogenesis (drug effects), MAP Kinase Signaling System, Mice, Panax notoginseng (chemistry), Phosphatidylinositol 3-Kinases (metabolism), Saponins (pharmacology), Signal Transduction, Vascular Endothelial Growth Factor C (metabolism), Zebrafish (embryology), p38 Mitogen-Activated Protein Kinases (metabolism).
- MESH :
- chemical , metabolism : Phosphatidylinositol 3-Kinases, Vascular Endothelial Growth Factor C, p38 Mitogen-Activated Protein Kinases.
- chemistry : Panax notoginseng.
- drug effects : Lymphangiogenesis.
- embryology : Zebrafish.
- enzymology : Endothelial Cells.
- metabolism : Endothelial Cells.
- chemical , pharmacology : Saponins.
- Animals, Animals, Genetically Modified, Cell Line, MAP Kinase Signaling System, Mice, Signal Transduction.
Abstract
Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H.Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases. The aim of this study was to determine the effect and mechanism of PNS on lymphangiogenesis.
DOI: 10.1016/j.jep.2016.08.032
PubMed: 27553977
Affiliations:
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Le document en format XML
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Electronic address: yjwang8888@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Qi" sort="Shi, Qi" uniqKey="Shi Q" first="Qi" last="Shi">Qi Shi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. 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Electronic address: phjod@163.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: 952026015@qq.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. 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Electronic address: yjwang8888@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Shi, Qi" sort="Shi, Qi" uniqKey="Shi Q" first="Qi" last="Shi">Qi Shi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: jzyjs200032@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author><author><name sortKey="Liang, Qianqian" sort="Liang, Qianqian" uniqKey="Liang Q" first="Qianqian" last="Liang">Qianqian Liang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China. Electronic address: liangqianqiantcm@126.com.</nlm:affiliation><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Orthopaedics, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032</wicri:regionArea><wicri:noRegion>Shanghai 200032</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of ethnopharmacology</title><idno type="eISSN">1872-7573</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Cell Line</term><term>Endothelial Cells (enzymology)</term><term>Endothelial Cells (metabolism)</term><term>Lymphangiogenesis (drug effects)</term><term>MAP Kinase Signaling System</term><term>Mice</term><term>Panax notoginseng (chemistry)</term><term>Phosphatidylinositol 3-Kinases (metabolism)</term><term>Saponins (pharmacology)</term><term>Signal Transduction</term><term>Vascular Endothelial Growth Factor C (metabolism)</term><term>Zebrafish (embryology)</term><term>p38 Mitogen-Activated Protein Kinases (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animal génétiquement modifié</term><term>Animaux</term><term>Cellules endothéliales (enzymologie)</term><term>Cellules endothéliales (métabolisme)</term><term>Danio zébré (embryologie)</term><term>Facteur de croissance endothéliale vasculaire de type C (métabolisme)</term><term>Lignée cellulaire</term><term>Lymphangiogenèse ()</term><term>Panax notoginseng ()</term><term>Phosphatidylinositol 3-kinases (métabolisme)</term><term>Saponines (pharmacologie)</term><term>Souris</term><term>Système de signalisation des MAP kinases</term><term>Transduction du signal</term><term>p38 Mitogen-Activated Protein Kinases (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Phosphatidylinositol 3-Kinases</term><term>Vascular Endothelial Growth Factor C</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Panax notoginseng</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lymphangiogenesis</term></keywords><keywords scheme="MESH" qualifier="embryologie" xml:lang="fr"><term>Danio zébré</term></keywords><keywords scheme="MESH" qualifier="embryology" xml:lang="en"><term>Zebrafish</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cellules endothéliales</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelial Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules endothéliales</term><term>Facteur de croissance endothéliale vasculaire de type C</term><term>Phosphatidylinositol 3-kinases</term><term>p38 Mitogen-Activated Protein Kinases</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Saponines</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Saponins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Animals, Genetically Modified</term><term>Cell Line</term><term>MAP Kinase Signaling System</term><term>Mice</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animal génétiquement modifié</term><term>Animaux</term><term>Lignée cellulaire</term><term>Lymphangiogenèse</term><term>Panax notoginseng</term><term>Souris</term><term>Système de signalisation des MAP kinases</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lymphatic system plays an important role in maintaining the fluid homeostasis and normal immune responses, anatomic or functional obstruction of which leads to lymphedema, and treatments for therapeutic lymphangiogenesis are efficiency for secondary lymphedema. Total saponins of panaxnotoginseng (PNS) are a mixture isolated from Panaxnotoginseng (Burkill) F.H.Chen, which has been used as traditional Chinese medicine in China for treatment of cardio- and cerebro-vascular diseases. The aim of this study was to determine the effect and mechanism of PNS on lymphangiogenesis.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Li, Jinlong" sort="Li, Jinlong" uniqKey="Li J" first="Jinlong" last="Li">Jinlong Li</name></noRegion><name sortKey="Chen, Yan" sort="Chen, Yan" uniqKey="Chen Y" first="Yan" last="Chen">Yan Chen</name><name sortKey="Liang, Qianqian" sort="Liang, Qianqian" uniqKey="Liang Q" first="Qianqian" last="Liang">Qianqian Liang</name><name sortKey="Shi, Qi" sort="Shi, Qi" uniqKey="Shi Q" first="Qi" last="Shi">Qi Shi</name><name sortKey="Wang, Yongjun" sort="Wang, Yongjun" uniqKey="Wang Y" first="Yongjun" last="Wang">Yongjun Wang</name><name sortKey="Xu, Hao" sort="Xu, Hao" uniqKey="Xu H" first="Hao" last="Xu">Hao Xu</name><name sortKey="Zhang, Li" sort="Zhang, Li" uniqKey="Zhang L" first="Li" last="Zhang">Li Zhang</name></country><country name="États-Unis"><region name="État de New York"><name sortKey="Xing, Lianping" sort="Xing, Lianping" uniqKey="Xing L" first="Lianping" last="Xing">Lianping Xing</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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